Takeaway
Longitudinal decline in resting-state functional connectivity (RSFC) can predict cognitive decline in Parkinson’s disease (PD) and precedes the onset of dementia.
Why this matters
Biomarkers for cognitive decline are urgently needed in PD as a large proportion of patients with PD will develop dementia.
PD disrupts functional connectivity in the brain but it is not known if the disruption is linked to dysfunctional proteins or if the changes occur before dementia.