Takeaway
Common genetic autosomal variations do not explain sex-specific differences in Parkinson's disease prevalence.
Why this matters ?
Genome-wide association studies have identified numerous genetic risk factors for Parkinson’s disease, but the genetic causes of differences in disease prevalence between males and females remains unclear.
These findings, obtained using multiple large case-control cohorts, suggest that the prevalence disparity is not explained by differences in sex chromosomes, suggesting that environmental effects could contribute to Parkinson’s disease sex-specific etiology.