Seizure prevalence in neuropathologically confirmed neurodegenerative disease

Takeaway

  • Seizures are a common comorbidity of neurodegenerative disease – particularly Alzheimer’s disease (AD) – and first neurodegenerative symptoms may inform seizure risk.

Why this matters

  • Approximately 50% of epilepsies in elderly people are of unknown cause and could be attributed to presymptomatic neurodegenerative disease.

  • Identification of first neurodegenerative symptom as a potential predictor of seizure risk may allow for more rapid management of epilepsy in these patients.