Takeaway
Myelin oligodendrocyte glycoprotein antibody (MOG-Ab) testing should not be performed in typical multiple sclerosis (MS) presentation, because there is a low frequency of positivity.
Why this matters
MOG-Abs are typically found in people with neuromyelitis optica clinical phenotype, however, recent studies have indicated that people with MS may also produce MOG-Abs.
Understanding the frequency of MOG-Ab in the MS population may lead to improvements in clinical diagnosis.