Immune cell profiles in patients with Parkinson disease

Takeaway

  • Antibody-independent functions of B cells and abnormal interactions between follicular T cells and B cells may be involved in Parkinson disease (PD) pathogenesis.

Why this matters ?

  • PD affects more than 6 million people worldwide and the etiology remains unclear; however, emerging evidence indicates that the immune system may be involved in the pathogenesis of PD.

  • Studies that have examined circulating immune cells in patients with PD have mainly focused on T cells but little is known about the interactions between T cells and non-T cells in patients with PD.