Anatomical findings associated with repetition deficits in primary progressive aphasia


  • Repetition deficits in progressive aphasia (PPA) are associated with damage to an indirect pathway that connects temporal and frontal regions via the parietal lobe.

Why this matters

  • It is unclear if repetition deficits in PPA are related to lesions of the arcuate fasciculus (direct pathway) or the inferior parietal lobe (indirect pathway).

  • The findings suggest that both the temporo-parietal cortex and the anterior and posterior segments should be included in updated language networks for educational and clinical uses.